Brca1 And Brca2 Factors That Affect The Risk Of Breast...

The second similarity is that both BRCA1 and BRCA2 bind to Rad5 protein that is involved in maintain the integrity of the genome (Kinzler et al, 1997). A mutation in the AT, or ATM, gene on chromosome 11 also is associated with breast cancer, and it may be much more common in the general population than BRCA1 or BRCA2 mutations. Seven percent of familial breast cancer may be associated with the AT gene mutation (Radford and Zehnbauer, 1996, cited in McCain, 1997). It is not known whether the AT mutation increases the risk of breast cancer for men. Ataxia teleangiectasia is an autosomal recessive neurologic syndrome. The cancer incidence among those people who inherit two copies of the AT mutation, and who are affected by Ataxia teleangiectasia syndrome, is 100 times greater that the general population. Women who have inherited one copy of the mutation (approximately 1.4% of the general population) may be more susceptible to breast cancer. Women with mutations in the p53 gene also may be at increased risk of developing breast cancer. However, mutations of the p53 gene are rare, affecting an estimated 1 in 10,000 individuals (Athma et al., 1996 cited in McCain, 1997). Mutations in HRAS1, the Cowden disease gene, p65, and TSG101 may also confer a higher risk of developing breast cancer (Easton et al., 1993; Krontiris et al., 1993; Greene, 1997 cited in McCain, 1997). BRCA1 and BRCA2 mutations and breast cancer seem to be distributed among a variety of populations.Show MoreRelatedBreast Cancer- Leading Cause of Death1436 Words   |  6 Pages Breast cancer continues to be the leading cause of death for middle aged women. In the past year, there were over 194,000 new cases of breast cancer in the U.S., approximately 20% of which did not access treatment in time despite the availability of educational resources. Breast cancer is a malignant tumor that develops in a female or male’s breast cells. Though the condition is not gender specific, it is most prevalent in middle aged to older women. It’s malignant foundation causes it to also conquerRead More Breast Cancer Susceptibility Genes BRCA1 and BRCA2 Essay2987 Words   |  12 PagesBreast cancer is the most common cancer that affects women in the United States. There are at least two majors genes (BRCA1 and BRCA2) that when they mutate can cause breast cancer. These genes can be pass ed from parent to child, increasing the risk of developing cancer in those child that have parent carrying these genes. BRCA1 and BRCA2 genes are located on chromosome 17 and chromosome 13 respectively. There is a 90% chance of developing breast cancer for a woman that has these mutated genes. InRead MoreTaking a Look at Breast Cancer1758 Words   |  7 PagesIntroduction Breast cancer is the most common cause of cancer-related death among females in the world. It is known for â€Å"have both a genetic and non-genetic etiology† (Milne et al., 2010). 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